IndraLab

Statements

USP7 activates SMAD3. 3 / 3
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"In addition, cell-free and cell-based analyses further demonstrate that the deubiquitinase activity of USP7 mediates the removal of mono-ubiquitin from SMAD3 and facilitates the DNA-binding of SMAD3-SMAD4 dimer at SMAD3 locus, and thus enhance the autoregulation of SMAD3."
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"This study demonstrates that USP7 promotes TGF-β1 signaling by stabilizing Smad2 and Smad3."
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"USP7 promotes positive self-regulation of SMAD3 by catalysing SMAD3 deubiquitination and inhibits the progression of p53-deficient lung cancer, suggesting that SMAD3 can play an anti-cancer role in lung cancer [95]."
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