IndraLab

Statements

PKC activates KCNH2. 14 / 15
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"The protein kinase C (PKC) inhibitor bisindolylmaleimide 1 (1muM) antagonized the reduction of mature hERG channel protein induced by Ang II."
25218469
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"It has been reported that sustained alpha 1A -adrenergic stimulation produced a profound augmentation of hERG channel protein mediated by PKC [32]."
25218469
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"Our results are consistent with calcium and/or DAG sensitive isotypes of PKC modulating hERG currents through a mechanism that involves direct phosphorylation of sites on the amino terminus of hERG."
17363390
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"In addition to the known effects of PKA and cAMP, HERG channels are also modulated by PKC."
12829172
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"Subsequently, it has been proposed that the PKC dependent modulation of hERG is exerted either independently of direct phosphorylation of the channel protein itself in Xenopus oocytes, or via a direct phosphorylation of the pore forming hERG subunits in mammalian cells."
22470342
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"Protein kinase A and protein kinase C modulate cardiac hERG channels and/or I Kr [6,7]."
18617000
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"The protein kinase C (PKC) inhibitor bisindolylmaleimide 1 (1muM) antagonized the reduction of mature hERG channel protein induced by Ang II."
25218469
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"We identified a specific role for the PKCepsilon inhibitory peptidomimmetics in decreasing PKC induced hERG tau activation (80%) and half-maximum activation voltage (90%) at steady state; a specific PKCepsilon activator exhibited the opposite effect."
24464434
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"Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein."
12829172
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"Stimulation of alpha1A-AR with phenylephrine or direct activation of PKC with phorbol ester increased HERG channel protein abundance and K (+) current density in a time- and dose dependent manner."
20463060
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"We identified a specific role for the PKCε inhibitory peptidomimmetics in decreasing PKC-induced hERG τ activation (80%) and half-maximum activation voltage (90%) at steady state; a specific PKCε activator exhibited the opposite effect."
24464434
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"Acute activation of PKC by PMA (30 nM, 30 min) reduced both hERG current (I hERG) and I Kr Chronic activation of PKC by PMA (30 nM, 16 h) increased I Kr in cardiomyocytes and the expression level of hERG proteins."
31015282
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"Protein kinases C (PKC) modulate the activity of the Kv11.1 ion channel current (hERG)."
24464434
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"We previously showed that PKC activation also increased the abundance of HERG channel by a mechanism (s) that only partially overlap with those for PKA [XREF_BIBR]."
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