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USP8 activates Pituitary ACTH Hypersecretion. 1 / 2
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"Notable examples include: the UCH family member BRCA1-associated protein 1 (BAP1), mutated in melanoma, mesothelioma and renal cell carcinoma ; USP6, translocated in aneurysmal bone cysts ; USP7, mutated in neurological disorders ; USP8, whose mutations cause Cushing disease ; USP9X, whose mutations cause developmental disorders and whose expression is dysregulated in cancer ; USP15, amplified in certain glioblastoma, breast and ovarian cancers ; and CYLD, commonly mutated in cylindromatosis ."