IndraLab

Statements

EGF leads to the phosphorylation of EGFR on Y1110. 10 / 10
2 | 7 1
bel
"H322 cells express wild-type EGFR and have no EGFR gene amplification. EGF led to the expected EGFR activation and later to increased levels of EphA2 protein (Fig. 5); both were significantly decreased by the use of the EGFR inhibitor erlotinib."
19531623
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"This downregulation of EGFR was accompanied by a pronounced and significant increase in the activating EGFR phosphorylation at Tyr1086 in response to EGF."
34785213
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"EGF stimulation resulted in rapid phosphorylation of EGFR (pEGFR Y1110) which was almost completely blocked by the EGFR kinase inhibitor, tyrphostin (AG1478) (XREF_FIG)."
26921391
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983
sparser
"Specifically, it was found that EGF-induced EGFR phosphorylation of Y845, Y1086, and Y1173 returned to baseline much faster, as compared to phosphorylation in response to epigen and epiregulin ( xref )."
38568193
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"Importantly, lenvatinib also significantly downregulated EGFR phosphorylation at the Tyr1086 site induced by EGF (Fig. 2F)."
39955573
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"As expected, EGF incubation greatly increased phosphorylation of EGFR (Tyr 1068, Tyr 1086, Tyr 845) and extracellular signal-regulated kinase (ERK), but not JAK, Src or STATs."
38378560
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"EGF stimulation increased EGFR phosphorylation on Tyr1173 and Tyr1086 (XREF_FIG and XREF_SUPPLEMENTARY)."
21303971
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"Compared with untreated cells, tyrosine phosphorylation of phospholipase C-gamma1 was enhanced by EGF stimulation in glucosylceramide depleted cells, associated with enhanced tyrosine phosphorylation of the EGF receptor at Tyr 1068 and Tyr 1086 stimulated by EGF."
12771140
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"TSP1 and its EGF like repeats also increased phosphorylation of EGFR Tyr 845, Tyr 992, Tyr 1045, Tyr 1086, and Tyr 1173, activated phospholipase Cgamma, and increased cell migration."
19129184