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USP47 binds SNAI1. 18 / 18
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"These results underscore the role of USP47 in promoting EMT signaling and suggest that the rs72856331 G allele enhances this effect, contributing to the aggressive behavior of GC cells.Given the known interaction between USP47 and Snai1, a key modulator of EMT (34, 35), we hypothesized that USP47 might induce EMT activation by regulating deubiquitination and protein stability of Snai1 in GC."
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"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
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"Co-immunoprecipitation (Co-IP) assays using a USP47 antibody confirmed a physical interaction between USP47 and Snai1 ( xref )."
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"Taken together, these results indicate that USP47 interacts directly with Snail and impedes its ubiquitination and subsequent proteasomal degradation."
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"USP47 binds to Snail and triggers its deubiquitination."
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"However, under hypoxic conditions, USP47 binding to Snail was markedly enhanced (Fig.  xref )."
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"To visualize the interaction between Snail and USP47, we stained the DLD-1 cells with fluorescent probes detecting USP47 (red) and Snail (green)."
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"Notably, USP47 interacts directly with Snail and enhances its stability."
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"USP47 binds to Snail and triggers its deubiquitination."
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"However, under hypoxic conditions, USP47 binding to Snail was markedly enhanced."
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"This observation implies that USP47 binds to Snail and removes ubiquitins from it in the cytoplasm of DLD-1 cells."
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"To visualize the interaction between Snail and USP47, we stained the DLD-1 cells with fluorescent probes detecting USP47 (red) and Snail (green)."
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"Taken together, these results indicate that USP47 interacts directly with Snail and impedes its ubiquitination and subsequent proteasomal degradation."
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"This observation implies that USP47 binds to Snail and removes ubiquitins from it in the cytoplasm of DLD-1 cells."
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"It would be worthwhile determining whether USP47 can bind to Snail at the SNAG or zinc finger domains and whether such interaction contributes to stabilization of its substarte Snail."
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"Co-immunoprecipitation (Co-IP) assays using a USP47 antibody confirmed a physical interaction between USP47 and Snai1 (Figure 6C)."
39998882
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"Given the known interaction between USP47 and Snai1, a key modulator of EMT ( xref , xref ), we hypothesized that USP47 might induce EMT activation by regulating deubiquitination and protein stability of Snai1 in GC."
39998882
sparser
"Notably, USP47 interacts directly with Snail and enhances its stability."
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