IndraLab

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Modified USP13 increases the amount of PTEN. 2 / 2

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"Collectively, these data suggest that loss of USP13 may contribute to loss of PTEN in a substantial fraction of human tumors, whereas in other tumors PTEN can be inactivated by different mechanisms, including genetic alterations and upregulation of PTEN ubiquitin ligases (such as NEDD4-1 14 and WWP2 15)."

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"Additionally, we noticed that in fibroblasts, the loss of USP13 down-regulated PTEN protein expression by increasing PTEN ubiquitination."

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IndraLab

Statements

Modified USP13 increases the amount of PTEN. 2 / 2

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