IndraLab

Statements

BAP1 decreases the amount of GPX4. 5 / 5
| 5
reach
"In this study, the overexpression of BAP1 significantly inhibited GPX4 expression and exacerbated the degree of lipid peroxidation and ferroptosis in neurons after SAH."
40080966
reach
"Furthermore, FOXO3a inhibition also inhibited the mRNA and protein expression levels of BAP1, while simultaneously increasing the levels of SLC7A11 and GPX4 after SAH in mice (Fig. 8C–F)."
40080966
reach
"Moreover, as revealed by western blot assay, knockdown of BAP1 also upregulated the expression of GPX4 reduced by LPS (Fig. 5H and I; CON vs. LPS, p = 0.002; NC(-) vs. BAP1(-), p = 0.004) and downregulated the expression of ASCL4 elevated by LPS (Fig. 5H and J; CON vs. LPS, p = 0.002; NC(-) vs. BAP1(-), p = 0.01), which were the marker proteins of ferroptosis."
38816686
reach
"In addition, overexpression of BAP1 reversed the effects of Exos , decreased the expression levels of SLC7A11 and GPX4, and increased the ACSL4, which was analyzed by RT-qPCR and western blot (Figures 6F and 6G)."
39391723
reach
"Our results revealed that transfection with H2Aub K119R mutant plasmid reduced the transcription and protein expression of SLC7A11 and GPX4, and overexpression of BAP1 can promote neuronal ferroptosis by regulating H2Aub levels."
40080966