IndraLab

Statements

USP8 activates ENaC. 3 / 3
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"USP8 increased ENaC current in Xenopus oocytes and collecting duct epithelia and enhanced ENaC abundance at the cell surface in HEK 293 cells."
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"Thus, USP8 and USP2-45 selectively modulate ENaC trafficking at different steps in the endocytic pathway."
23297398
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"This resulted from altered endocytic sorting; USP8 abolished ENaC degradation in the endocytic pathway, but it had no effect on ENaC endocytosis."
23297398