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USP8 activates ENaC. 6 / 6
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"Therefore, USP8 may enhance the ENaC activity in PE caused by this dysregulated pathway, which promotes trophoblast cell invasion and vascular remodeling.Embryo implantation has been shown to be assoc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In summary, these observations suggest that USP8 expression was significantly correlated with the proliferation, migration, invasion, and pro-angiogenesis function of trophoblastic cells.ENaC has been[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, USP8 selectively enhances ENaC at the cell surface without altering its total abundance in the HTR8/SVneo cells.We silenced the SCNN1A gene, also known as α-ENaC, in the HTR8/SVneo cells and the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP8 increased ENaC current in Xenopus oocytes and collecting duct epithelia and enhanced ENaC abundance at the cell surface in HEK 293 cells."
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"Thus, USP8 and USP2-45 selectively modulate ENaC trafficking at different steps in the endocytic pathway."
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"This resulted from altered endocytic sorting; USP8 abolished ENaC degradation in the endocytic pathway, but it had no effect on ENaC endocytosis."
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