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CYLD inhibits TRAF2. 10 / 14
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"Thus, CYLD inhibits MyD88, RIP1 (receptor-interacting serine/threonine-protein kinase 1), TRAF2, TRAF6, TRAF7, and NEMO downstream to TLR signaling and regulates exaggerated inflammation which can lea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD also inhibits TRAF2 and NEMO (NF-κB essential modulator, a regulatory subunit of IKK), and blocks NF-κB signaling downstream to TLR activation [176-178] ."
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"Phosphorylation at S418 weakens the catalytic efficiency of CYLD, which impairs the degradation of its substrates TRAF2 and TRAF6 and, consequently, promotes NF-κB signalling."
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"Similarly to active-site C601 CYLD mutants ( Trompouki et al. , 2003 ; this work), CYLD-D681G was unable to inhibit TRAF2- or TRAF6-mediated activation of NF- κ B and TNF α activation of JNK, and to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD was shown to inactivate TRAF2, TRAF6, and IKKγ by removing the K63-linked polyubiquitin chains ( Kovalenko et al., 2003 ), whereas A20 removes K63-linked polyubiquitin chains from TRAF2, TRAF6, a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, de-ubiquitinating enzyme cylindromatosis (CYLD) inhibits NF-kappaB signaling via de-ubiquitination and inactivation of TNFR associated factor 2 (TRAF2) and TRAF6 [XREF_BIBR, XREF_BIBR]; de-ubiquitinating protease A20 inhibits NF-kappaB activation induced by Toll like receptor 4 (TLR4) via removing K63 linked polyubiquitin chains of TRAF6 [XREF_BIBR]."
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"Similarly, another DUB, cylindromatosis (CYLD), functions as a tumor suppressor and eliminates K63-linked Ub molecules from TNFR-associated factor 2 (TRAF2) [182]."
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"CYLD also inhibits TRAF2 and NEMO (NF-κB essential modulator, a regulatory subunit of IKK), and blocks NF-κB signaling downstream to TLR activation [176] [177] [178] ."
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"CYLD also inhibits TRAF2 and NEMO (NF-kappaB essential modulator, a regulatory subunit of IKK), and blocks NF-kappaB signaling downstream to TLR activation [176] [177] [178]."
| DOI
reach
"CYLD also inhibits TRAF2 and NEMO (NF-κB essential modulator, a regulatory subunit of IKK), and blocks NF-κB signaling downstream to TLR activation [176-178] ."
33075714