IndraLab

Statements

USP4 inhibits Wnt. 4 / 4
| 2 2
eidos
"Conversely , USP4 inhibits Wnt signaling by deubiquitinating Dvl ."
36340031
eidos
"By contrast , USP4 was reported to inhibit Wnt signaling by deubiquitinating the polyubiquitin chains on dishevelled ( Dvl / Dsh ) and blocking Wnt3a-induced osteoblast differentiation and bone formation ( Zhou et al ., 2016 ) ."
36340031
reach
"In this study, we found ubiquitin specific peptidase 4 (USP4) to strongly inhibit the Wnt and beta-catenin signaling by removing Lysine 63 linked poly-ubiquitin chain from Dishevelled (Dvl)."
27128386
reach
"USP4 negatively regulates Wnt signaling by interacting with Nemolike kinase [XREF_BIBR] and USP15 promotes beta-catenin degradation through the stabilization of adenomatous polyposis coli (APC), a negative regulator of Wnt mediated transcription [XREF_BIBR]."
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