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NKX2-5 increases the amount of HCN4. 2 / 2
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"This myocardium is devoid of the important cardiac transcription factor Nkx2-5, which in turn, prevents expression of the gap junctional protein connexin 40, required for fast conduction, but allows e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Since hypomorphism of Nkx2-5 causes augmentation of Hcn4 expression in the Nkx2-5 + / Shox2 + PV myocardium [XREF_BIBR], and that the Shox2 + / Hcn4 + SV myocardium is negative for Nkx2-5, it was proposed that Nkx2-5 inhibits pacemaker properties that belong to a primitive cell phenotype, and such effect is counter balanced by Shox2."
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