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NKX2-5 increases the amount of HCN4. 2 / 2

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"Since hypomorphism of Nkx2-5 causes augmentation of Hcn4 expression in the Nkx2-5 + / Shox2 + PV myocardium [XREF_BIBR], and that the Shox2 + / Hcn4 + SV myocardium is negative for Nkx2-5, it was proposed that Nkx2-5 inhibits pacemaker properties that belong to a primitive cell phenotype, and such effect is counter balanced by Shox2."

26682210

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"The results revealed that Nkx2.5 silencing increased HCN4 expression, decreased Cx40 expression and disrupted the expression of calcium handling proteins."

31798700

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IndraLab

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NKX2-5 increases the amount of HCN4. 2 / 2

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