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USP48 activates Caspase. 2 / 2
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"To test this hypothesis, we transiently transfected recombinant USP48 protein into A20 knockdown cells and found that USP48 rescued H. pylori-induced caspase cleavages in parental cells but not in A20-depleted cells (Fig. 4a)."
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"Furthermore, transfection of A20 protein in USP48-depleted cells before H. pylori infection suppressed caspase cleavage and apoptotic cell death (Fig. 4c), indicating that the protective effect on apoptotic cell death is dependent on the expression of A20."
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