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Mutated SCN5A activates BrS. 2 / 2

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"The primary pathophysiological mechanism underlying BrS is driven by SCN5A mutations, resulting in the loss of function (LoF) of the late cardiac sodium current (INa)."

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"For instance, SCN5A mutations can cause not only LQT3 and BrS, but also cardiac conduction disease, sick sinus syndrome, atrial fibrillation, or dilated cardiomyopathy."

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IndraLab

Statements

Mutated SCN5A activates BrS. 2 / 2

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