IndraLab

Statements

Genistein inhibits JUN. 6 / 6
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"H7 (50 microM), genistein (2 microM) and okadaic acid (20 nM), all block the induction of c-jun and c-fos mRNA accumulation in the H2O2 treated rat lenses."
7835407
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"Western blotting demonstrated that the expressions of c-jun and c-fos protein were decreased gradually after being treated with 20 micromol/L genistein for 12 - 72 h. Genistein could down-regulate the expression of two key genes, c-erbB-2 and c-raf-1 at mRNA and protein level in the EGFR mediated signal transduction pathway, and down-regulate the expression of its downstream nuclear transcription factors c-jun and c-fos at mRNA and protein level."
15634453
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"Furthermore, genistein has also been shown to block SV-40-induced upregulation of c-myc and c-jun and to cause a delay in the onset of SV-40 DNA synthesis ( Dangoria et al., 1996 )."
17182070
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"Activator protein 1 activation in response to either high glucose or co-stimulation with high glucose and Ang II was inhibited completely by calphostin C (a PKC inhibitor) and partially by genistein (a protein tyrosine kinase inhibitor)."
11440364
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"Given that there is important crosstalk between AR and mitogen activated protein kinase (MAPK) signaling, we also investigated whether genistein activates the MAPK end targets c-Jun N-terminal kinase (JNK) and c-Jun."
18425381
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"Topical genistein was shown to prevent c-Jun and collagenase up-regulation after UV exposure in human skin in vivo ( Kang et al., 2003 )."
17933593