IndraLab

Statements

USP8 activates cell migration. 7 / 7
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"Silencing of USP8 suppresses PCa cell migration and promotes docetaxel activity."
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"Similarly, in PC3, silencing of USP8 was found to have significantly reduced cell migration rates at 20.6 ± 2.0%, 34.1 ± 2.7%, and 71.0 ± 2.5% compared to control at 34.9 ± 2.1%, 65.7 ± 2.6%, and 95.3 ± 2.3% over 24, 48, and 48 h, respectively ( Figures 2A2, B2 )."
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"Therefore, similar to the wound healing assay, it could be stated that USP8 overexpression increased the PCa cell migration and diminished the effect of docetaxel on PCa migration."
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"Its overexpression increased the PCa cell migration and diminished the healing action of docetaxel in both cells.Similar to the wound healing assay, overexpression of USP8 resulted in the highest number of migrated cells for both Du145 and PC3 cells in the Transwell assay, which showed statistical significance compared to all other treatment group cells ( Figure 3B )."
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"Finally, we show that knockdown of USP8 in human breast cancer cells suppresses cell migration."
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"In DU145, silencing of USP8 was found to have significantly reduced cell migration rates 16.8 ± 1.5%, 24.3 ± 2.6%, and 46.2 ± 1.4% compared to control with 28.6 ± 1.9%, 54.8 ± 3.2%, and 80.6 ± 3.7% at 24, 48, and 48 h, respectively ( Figures 2A1, B1 )."
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"Overexpression of USP8 promotes PCa cell migration and diminished docetaxel activity."
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