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PKP2 binds SCN5A. 8 / 8
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"For example, biochemical, patch clamp, and optical mapping experiments have reported important associations between plakophilin-2 and NaV1.5 at a cellular level while also demonstrating adverse effects of PKP2 knockdown on sodium current function."
37216437
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"Using a combination of conventional biochemistry, patch clamp, and optical mapping experiments, Sato et al. 15 showed for the first time that PKP2 associates with NaV1.5 and that knockdown of PKP2 expression alters the properties of the sodium current and the velocity of action potential propagation in cultured cardiomyocytes."
26987567
sparser
"These mutations can disrupt interactions between PKP2 and NaV1.5 at the cardiac intercalated disc, reducing the iNa (sodium current) and contributing to the development of BrS [ xref ]."
37443825
sparser
"In a subsequent study on cultured cardiomyocytes (Sato et al., xref ), it was shown that PKP2 associates with the SCN5A encoded sodium channel protein Na V 1.5 and that knockdown of PKP2 expression alters the properties of the sodium current."
22754532
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"These mutations can disrupt interactions between PKP2 and NaV1.5 at the cardiac intercalated disc, reducing the iNa (sodium current) and contributing to the development of BrS [63]."
37443825
sparser
"Based on these observations, we speculate that MYZAP interacts with PKP2 and Nav1.5, thereby affecting the development of atrial arrhythmia induced by MI."
39507261
sparser
"MYZAP binds directly to PKP2 and Nav1.5 proteins by co-immunoprecipitation experiments ( xref J)."
39507261
sparser
"This mechanism of cell membrane protein interaction prompted us to explore the effects of MYZAP and PKP2-Nav1.5 on atrial arrhythmia after MI."
39507261