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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

SCN5A binds PKP2. 2 / 2

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"In a subsequent study on cultured cardiomyocytes (Sato et al., xref ), it was shown that PKP2 associates with the SCN5A encoded sodium channel protein Na V 1.5 and that knockdown of PKP2 expression alters the properties of the sodium current."

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"86 The role of SCN5A in ARVC phenotypes can be explained by the fact that the desmosomal protein PKP2 (plakophilin-2) associates with Nav1.5, and the loss of function of PKP2 can alter the biophysical properties of Na + channels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...