IndraLab

Statements

Celastrol inhibits CASP1. 17 / 17
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"Similarly, the caspase-1 cleavage and IL-1beta secretion were also suppressed by celastrol after stimulation with different TLR."
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"Interestingly, we observed that celastrol inhibited caspase-1 cleavage and IL-1beta secretion, suggesting that celastrol effectively inhibited both LPS induced priming and inflammasome activation under different conditions (XREF_SUPPLEMENTARY)."
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"Celastrol significantly suppressed the cleavage of pro-caspase-1 and pro-IL-1beta, while not affecting the protein expressions of NLRP3, ASC, pro-caspase-1 and pro-IL-1beta in THP-1 cells, BMDMs and HEK293T cells."
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"Also in this case, celastrol administration decreased the activation of caspase-1 (XREF_FIG)."
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"Celastrol suppresses IL-1beta secretion and caspase-1 activation in mouse macrophages."
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"Celastrol inhibits the activation of NF-kB and caspase-1."
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"Taken together, these data indicate that celastrol inhibits NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation in both mice and human myeloid cells."
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"We found that pretreatment of celastrol effectively inhibited IL-1beta secretion and caspase-1 activation in BMDMs and BMDCs."
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"Consistently, celastrol dose-dependently suppressed caspase-1 activation and IL-1beta maturation, but no effects on pro-IL-1beta and pro-caspase-1 expression."
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"Furthermore, we observed that gambogic acid and celastrol inhibit caspase-1 and NF-kB activation."
| PMC
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"To assess the effect of celastrol on NLRP3 inflammasome activation, we first examined whether celastrol could inhibit caspase-1 cleavage and IL-1beta secretion."
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"Celastrol significantly suppresses inflammation by reducing the secretion of IL-1beta and IL-18, and inactivating the NLRP3 inflammasomes and caspase-1 in LPS and ATP primed macrophage cells."
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"Moreover, celastrol treatment markedly decreased mRNA expression caspase-1, NLRP3 and ASC in colon tissue."
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"We performed these NLRP3 agonists and found that celastrol also inhibited IL-1beta secretion and caspase-1 activation, but did not affect the secretion of TNF-alpha or IL-6 and the expression of pro-IL-1beta and pro-caspase-1, suggesting that celastrol is a potent and broad inhibitor of NLRP3 inflammasome."
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"In addition, celastrol treatment dramatically decreased caspase-1 cleavage in macrophages from DSS fed mice."
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"To further confirm that celastrol could inhibit caspase-1 activation, cell lysates from celastrol treated LPS primed macrophages was reacted with recombinant active caspase-1."
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"We can thus conclude that celastrol inhibits NF-kB and caspase-1 activation."
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