IndraLab

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USP4 leads to the deubiquitination of RAB7A. 3 / 3
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"In summary, our findings collectively suggest that reduced USP4 levels mediate RAB7A ubiquitination, disrupting lysosomal trafficking and autophagosome-lysosome fusion, which contributes to the development and progression of periodontitis.As evidenced by numerous studies, autophagy plays a dual and complex role in the preservation of periodontal homeostasis [46–48]."
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"USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis."
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"In this study, our investigation revealed that the ubiquitination of RAB7A, mediated by reduced levels of the deubiquitinating enzyme USP4 (ubiquitin specific peptidase 4), disrupts normal lysosomal trafficking and autophagosome-lysosome fusion, thereby contributing significantly to periodontitis progression."
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