IndraLab

Statements

reach
"SLO inhibits MDA MB 231 breast cancer cell invasion."
21787862
reach
"Knocking down the beta3, but not the beta1, subunit of KCa1.1 attenuates the ex vivo invasiveness of RA-FLS."
27165430
reach
"Accordingly, KCNMA1 overexpression was not sufficient to inhibit the migration and invasion of gastric cancer cells after PTK2 knockdown [XREF_BIBR]."
30791468
reach
"Our evidence that SLO inhibited cancer cell invasion in a surrogate assay for metastasis led us to investigate whether SLO caused changes in the levels of mRNA from genes associated with tumor metastasis."
21787862
reach
"In addition, miR-211 targets KCNMA1 mRNA 3 '-UTR to suppress melanoma cell migration and invasion."
29375300
reach
"Consistently, breast cancer cell migration and invasion is decreased by inhibition of the BK channel (60)."
34988012
sparser
"Here we report that oxidized SLO also significantly inhibited invasion by human metastatic breast cancer MDA-MB-231 cells through Matrigel in an in vitro model of metastatic disease."
21787862
reach
"Besides, miR-211 overexpression could result in decreased BRN2 protein [XREF_BIBR] and the ion channel KCNMA1 [XREF_BIBR] expression to inhibit cellular invasion."
30821276
sparser
"SLO inhibits MDA MB 231 breast cancer cell invasion."
21787862
reach
"Cell invasion through Matrigel was inhibited by dose dependent addition of SLO."
21787862
reach
"Although the benefits of SLO in cancer responsiveness are limited, Hall et al. report that SLO can reduce breast cancer invasion and cell growth by activating the ErbB1 kinase, a protein encoded by the epidermal growth factor receptor gene involved in cell signaling and proliferation (59)."
37588093
sparser
"Our evidence that SLO inhibited cancer cell invasion in a surrogate assay for metastasis led us to investigate whether SLO caused changes in the levels of mRNA from genes associated with tumor metastasis."
21787862
sparser
"The results demonstrate that inhibition of cell invasion by SLO is dependent on the expression of EGFR in MDA-MB-231 cells."
21787862
reach
"Knockdown of EGFR by siRNA prevented SLO inhibition of invasion, indicating that the EGFR is required for response to SLO."
21787862
reach
"Furthermore, treating cells with siRNA that targeted the KCNMA1 gene inhibited the invasion of breast cancer cell lines to a similar extent as did treating them with IBTX."
19640305
reach
"SLO inhibition of invasion is dependent on EGFR."
21787862
reach
"To determine if SLO inhibition of invasion that correlated to activation of EGFR actually required the EGFR we used siRNA to knockdown EGFR in MDA-MB-231 cells and a non coding siRNA as a control."
21787862