IndraLab

Statements



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"In addition, miR-211 targets KCNMA1 mRNA 3 '-UTR to suppress melanoma cell migration and invasion."

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"SLO inhibits MDA MB 231 breast cancer cell invasion."

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"Knockdown of EGFR by siRNA prevented SLO inhibition of invasion, indicating that the EGFR is required for response to SLO."

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"Consistently, breast cancer cell migration and invasion is decreased by inhibition of the BK channel (60)."

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"Accordingly, KCNMA1 overexpression was not sufficient to inhibit the migration and invasion of gastric cancer cells after PTK2 knockdown [XREF_BIBR]."

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"Besides, miR-211 overexpression could result in decreased BRN2 protein [XREF_BIBR] and the ion channel KCNMA1 [XREF_BIBR] expression to inhibit cellular invasion."

sparser
"Our evidence that SLO inhibited cancer cell invasion in a surrogate assay for metastasis led us to investigate whether SLO caused changes in the levels of mRNA from genes associated with tumor metastasis."

sparser
"The results demonstrate that inhibition of cell invasion by SLO is dependent on the expression of EGFR in MDA-MB-231 cells."

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"Cell invasion through Matrigel was inhibited by dose dependent addition of SLO."

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"Our evidence that SLO inhibited cancer cell invasion in a surrogate assay for metastasis led us to investigate whether SLO caused changes in the levels of mRNA from genes associated with tumor metastasis."

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"Knocking down the beta3, but not the beta1, subunit of KCa1.1 attenuates the ex vivo invasiveness of RA-FLS."

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"Furthermore, treating cells with siRNA that targeted the KCNMA1 gene inhibited the invasion of breast cancer cell lines to a similar extent as did treating them with IBTX."

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"SLO inhibition of invasion is dependent on EGFR."

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"Here we report that oxidized SLO also significantly inhibited invasion by human metastatic breast cancer MDA-MB-231 cells through Matrigel in an in vitro model of metastatic disease."

sparser
"SLO inhibits MDA MB 231 breast cancer cell invasion."

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"To determine if SLO inhibition of invasion that correlated to activation of EGFR actually required the EGFR we used siRNA to knockdown EGFR in MDA-MB-231 cells and a non coding siRNA as a control."