IndraLab

Statements

COPS6 binds NPM1. 13 / 13
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"Indeed, three proteins involved in gemcitabine drug resistance have been characterized in our CSN6‐NPM1 axis."
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"Collectively, these results indicate that the CSN6‐NPM1 axis and downstream ribosome biogenesis are augmented in gemcitabine‐resistant PDAC cells, potentially contributing to gemcitabine resistance."
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"NSC348884, a small‐molecule inhibitor targeting NPM1, disrupts its biological function via oligomerization interference (Figure xref , Supporting Information). [ xref , xref ] To assess the therapeutic potential of targeting the CSN6‐NPM1 axis for suppressing PDAC progression and overcoming gemcitabine resistance, we therefore treated PDAC cell lines with NSC348884."
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"Conversely, pharmacological inhibition of the CSN6‐NPM1 axis suppresses tumor growth and alleviates gemcitabine resistance."
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"To determine the clinical significance of targeting the CSN6‐NPM1 axis with NSC348884, we subcutaneously implanted CSN6‐OE BXPC‐3 cells into nude mice and administered gemcitabine or NSC348884 via intraperitoneal injection every other day."
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"In conclusion, these data demonstrate that gemcitabine‐NSC348884 combination suppresses the CSN6‐NPM1 regulatory axis and may serve as a promising therapeutic strategy for PDAC patients with high CSN6 expression."
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"Targeting the CSN6‐NPM1 signaling axis by combined‐treatment with gemcitabine and an NPM1 inhibitor (NSC348884) improves the therapeutic efficacy of gemcitabine in CSN6‐high PDAC."
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"CSN6 Binds to NPM1 and Stabilizes it by Modulating Ubiquitination, Thereby Promoting NPM1‐Mediated Ribosome Biogenesis and Cell Growth."
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"In conclusion, our results demonstrate a CSN6‐NPM1 link in PDAC progression."
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"Collectively, these data demonstrate that CSN6‐NPM1 interaction plays a pivotal role in rRNA transcription and ribosome biogenesis."
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"In line with CSN6‐mediated gemcitabine resistance, CSN6‐NPM1 axis enhances ribosome biogenesis, thereby promoting translation of gemcitabine resistance genes, including Cytidine deaminase (CDA), Ribonucleotide reductase subunit M1/2 (RRM1/2)."
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"Taken together, these findings demonstrate that the CSN6‐NPM1 axis promotes ribosome biogenesis and enhances cell proliferation."
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