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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified UCHL1 inhibits APP. 2 / 2

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"Furthermore, overexpression of UCHL1 reduces the production of Abeta by downregulating the protein level of beta-secretase and APP [XREF_BIBR, XREF_BIBR]."

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"Moreover, overexpression of UCHL1 reduces the levels of beta-secretase BACE1, and consequent BACE1 cleavage products (APP C-terminal fragment C99 and Abeta)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...