IndraLab

Statements

P38 phosphorylates KCNB1. 18 / 19
| 2 14 2
sparser
"Interestingly, NS5A inhibited oxidative stress-induced p38 MAPK phosphorylation of Kv2.1."
21168955
sparser
"However, the apoptotic surge of Kv2.1 channel activity is only possible via a p38-dependent increase in Kv2.1 phosphorylation [ xref ] and, since retinal Kv2.1 subunits are less phosphorylated than cortical Kv2.1 [ xref ], it could also explain why photoreceptor cell death progresses mildly in CDSRR."
| PMC
sparser
"This process is triggered by the phosphorylation of Kv2.1 by Src and p38 kinases at two distinct intracellular n- and c-terminal residues of the channel, Y124 and S800 ( xref , xref )."
22745487
sparser
"Combining molecular, biochemical and electrophysiological techniques, we establish Src kinase as a critical upstream signaling modulator facilitating p38 MAPK phosphorylation of Kv2.1."
26115091
sparser
"Since this result suggested a different mechanism of action by the viral protein than that suggested by xref , we investigated the status of p38 phosphorylation of Kv2.1 in CHO cells expressing NS5A1b."
22745487
sparser
"The HCV NS5A protein mediated this effect by inhibiting oxidative stress-induced p38 MAPK phosphorylation of Kv2.1."
19717445
sparser
"In addition, a phospho-specific antibody for S800 detects a p38-dependent increase in Kv2.1 phosphorylation in apoptotic neurons and reveals phosphorylation of S800 in immunopurified channels incubated with active p38."
17360683
sparser
"The phosphorylation of Kv2.1 by p38 MAPK occurs specifically at the S800 residue of the intracellular C-terminus [ xref ], while Src mainly phosphorylates an N-terminal residue, Y124 [ xref ]."
26115091
sparser
"Cysteine mutations influence p38 phosphorylation of Kv2.1."
26115091
sparser
"In previous studies [ xref , xref ], we reported that the phosphorylation of Kv2.1 by Src and p38 kinases is associated with oxidant-triggered apoptotic K + current surges in transfected CHO cells."
26115091
sparser
"Together, these data indicate that although NS5A1b can depress basal Kv2.1-mediated currents in neurons and in a recombinant expression system, as well as limit the apoptotic surge in neurons, it likely does not interfere with p38 phosphorylation of Kv2.1."
22745487
sparser
"Additional studies revealed that the apoptotic potassium current surge results from a zinc-activated phosphorylation of Kv2.1 by both Src and p38, which in turn, induces a syntaxin-dependent de novo insertion of large number of Kv2.1 channels into the plasma membrane ( xref ; xref , xref ; xref )."
32792905
rlimsp
"Consequently, phosphorylation of Kv2.1 residue S800 by p38 leads to trafficking and membrane insertion during apoptosis, and remarkably, the absence of S800 phosphorylation is sufficient to prevent completion of the cell death program."
17360683
sparser
"In an attempt to ascribe a function to the P2 motif, we previously reported that HCV attenuates outward K + currents mediated by the Kv2.1 channel in a P2 dependent manner ( xref ), whereby channel activity was found to be impaired by inhibition of p38MAPK phosphorylation of serine 800 (S800) in the C-terminal cytoplasmic domain of Kv2.1."
23857585
reach
"The HCV NS5A protein mediated this effect by inhibiting oxidative stress-induced p38 MAPK phosphorylation of Kv2.1."
19717445
rlimsp
"Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1."
17360683
reach
"30 Even though the oligomerization and insertion mechanisms are thought to be uncoupled and to be active during distinct phases of the apoptotic process, 18 it is possible that integrins may indirectly affect the phosphorylation of KCNB1 by p38 in pathological conditions through their modulation of Src signaling."
28383553
sparser
"It was recently demonstrated that in response to oxidative stress, activated p38MAPK phosphorylates the Kv2.1 protein, which mediates an K + efflux with a concomitant induction of apoptosis ( xref , xref )."
23857585