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Empagliflozin inhibits NLRP3. 9 / 9
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"Of note, empagliflozin attenuated activation of the NLRP3 inflammasome and expression of associated markers of sterile inflammation in hearts from mice with HFrEF, implicating reduced cardiac inflammation as a mechanism of empagliflozin that contributes to sustained function in HFrEF in the absence of diabetes mellitus."
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"Empagliflozin attenuated the activation of NLRP3 inflammasome in a Ca 2+ -dependent manner XREF_BIBR."
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"Empagliflozin (a different SGLT-2 inhibitor) has also been determined to impede the kindling of NLRP3 inflammasome and decrements downstream inflammatory signaling in the diabetic kidneys in another study [17]."
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"71 Metformin and empagliflozin, two well-known antidiabetic drugs, inhibited NLRP3 inflammasome and decelerated the development of diabetic cardiomyopathy but via different mechanisms."
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"Daily treatment of ulcerative rats with empagliflozin significantly reduced NLRP3 protein and mRNA expressions."
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"Empagliflozin inhibits NLRP3 inflammasomes, but the mechanism was likely associated with the regulation of ketones and insulin levels (Kim et al., 2020) or in a Ca 2+ -dependent manner (Byrne et al., 2020) ."
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"In HF rodent models, empagliflozin inhibited NLRP3 inflammasome in a Ca 2+ -dependent manner [284] ."
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"Empagliflozin Attenuates Obesity-Related Kidney Dysfunction and NLRP3 Inflammasome Activity Through the HO-1-Adiponectin Axis."
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"Byrne et al. ( 2020 ) showed that empagliflozin attenuated the NLRP3 level and then mitigated the inflammatory response in mice with HF , reducing cardiac fibrosis and remodeling ."
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