IndraLab

Statements

COPS5 inhibits proteolysis. 7 / 7
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"Jab1 and CSN5 over-expression accelerated the protein degradation of Rad1 and Hus1 significantly, but had a weaker effect on Rad9 and (b))."
17583730
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"However, when COPS5 is amplified and overexpressed in endocrine resistant cancer cells, elevated COPS5 and COP9 activity induces global NCoR protein degradation."
27375289
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"Therefore, unbalanced activity of Jab1 and CSN5 can directly or indirectly block ubiquitin dependent proteolysis [XREF_BIBR]."
17640378
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"Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex."
17583730
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"Silencing RNA knockdown or overexpression of CSN5 revealed that CSN5 promotes SIAH-1 expression, while CSN5 knockdown also attenuated SIAH-1 protein degradation."
24882689
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"Overexpression of Jab1 accelerated the protein degradation of BRSK2 significantly."
22609399
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"Inversely, overexpression of CSN5 by a Flag-CSN5 fusion construct led to accelerated SIAH-1 protein degradation."
24882689