IndraLab

Statements

COPS5 inhibits proteolysis. 8 / 8
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"Overexpression of Jab1 accelerated the protein degradation of BRSK2 significantly."
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"Silencing RNA knockdown or overexpression of CSN5 revealed that CSN5 promotes SIAH-1 expression, while CSN5 knockdown also attenuated SIAH-1 protein degradation."
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"Jab1 and CSN5 over-expression accelerated the protein degradation of Rad1 and Hus1 significantly, but had a weaker effect on Rad9 and (b))."
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"In this study, we demonstrated that Csn5 inhibits autophagy in M. oryzae by promoting ubiquitin-dependent Atg6 protein degradation and stabilizing the TOR pathway in autophagosome formation."
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"Moreover, the circRNA CircIGF2BP3 and lncRNA KCNQ1OT1 facilitate the stabilization of PD-L1 through targeting OTUB1 and USP22 respectively.91 103 In addition, BBR, compound-15 and shikonin are all reported to target the CSN5 to accelerate the protein degradation of PD-L1 by previous researches.117 118 120Although the anticancer potential of targeting E3s or DUBs has been reported by multitudes of emerging studies, there are still some significant problems that worth being further investigated."
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"However, when COPS5 is amplified and overexpressed in endocrine resistant cancer cells, elevated COPS5 and COP9 activity induces global NCoR protein degradation."
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"Therefore, unbalanced activity of Jab1 and CSN5 can directly or indirectly block ubiquitin dependent proteolysis [XREF_BIBR]."
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"Inversely, overexpression of CSN5 by a Flag-CSN5 fusion construct led to accelerated SIAH-1 protein degradation."
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