IndraLab

Statements

USP22 activates Neoplasms. 15 / 17
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"USP22 has been reported to promote tumor progression by participating in the mediation of DNA repair processes [38]."
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"Consistent with these findings, our data demonstrate that USP22 promotes gastric cancer cell proliferation, migration, and invasion in vitro and enhances tumor growth in vivo."
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"We performed rescue experiments to test whether ALKBH5’s tumor-promoting function may be mediated by USP22 and RNF40."
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"In vivo experiments reveal that USP22 knockdown in GC cells significantly reduces xenograft tumor growth and lung metastasis in SCID mice."
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"Despite these advances , the overall mechanisms by which USP22 contributes to cancer progression remain incompletely defined ."
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
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"To date , no small molecule inhibitors of USP22 have been reported , but given mounting evidence in multiple contexts that USP22 promotes tumor progression , the development of such inhibitors would be desirable ."
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"USP22 and RNF40 mediate tumor-promoting function of ALKBH5."
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"In sum , these studies identify USP22 as a regulator of the response to DNA damage , and ultimately define a major node by which USP22 promotes cancer phenotypes ."
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"A more recently published report indicates that USP22 may promote tumor progression and induce EMT in colorectal carcinoma patients [ 13 ] ."
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"Knockdown of USP22 in an in vivo model was shown to decrease tumor angiogenesis, impair non-homologous DNA damage repair pathways and significantly improve the therapeutic efficacy of cisplatin."
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"Apart from activating oncogenes such as BMI-1 and c-MYC , USP22 can inhibit the expression of tumor suppressors such as TP53 through ubiquitination , thus promoting proliferation of tumors [ 87 ] ."
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"Moreover, the depletion of USP22 was shown to decrease in vivo tumor growth ."
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"Downregulation of USP22 reduces in vitro cancer cell proliferation, survival, migration, and invasion, and decreases in vivo tumor growth and metastasis [6, 10–13]."
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"Previous studies have also shown that USP22 can promote tumor progression and induce EMT in various tumors [ 13 , 23 ] ."
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