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USP22 activates Neoplasms. 49 / 51
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"Moreover, the depletion of USP22 was shown to decrease in vivo tumor growth ."
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"We performed rescue experiments to test whether ALKBH5’s tumor-promoting function may be mediated by USP22 and RNF40."
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"In summary, USP22 downregulation reduces cancer cell proliferation, migration, and invasion and reduces tumor growth and metastasis in vivo."
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"Other studies also suggested that USP22 promotes tumor migration by promoting procancer pathways such as Wnt/β-Catenin and signal transducer and activator of transcription 3 (STAT3)/MMP9 [ 73 , 74 ]."
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"Knockdown of USP22 in an in vivo model was shown to decrease tumor angiogenesis, impair non-homologous DNA damage repair pathways and significantly improve the therapeutic efficacy of cisplatin."
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"Similar results have been reported in liver tumors (19), where ablation of USP22 in liver tumor cells has been shown to increase tumor immunogenicity and promote T-cell infiltration into the resulting liver tumors."
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"Downregulation of USP22 reduces in vitro cancer cell proliferation, survival, migration, and invasion, and decreases in vivo tumor growth and metastasis [6, 10–13]."
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"USP22 has been reported to promote tumor progression by participating in the mediation of DNA repair processes [38]."
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"For example, in hepatocellular carcinoma USP22 upregulates PD‐L1 and induces the exhaustion of tumor infiltrating CD8+ T cells, 32 while in the colorectal carcinoma it targets BMI‐1, c‐MYC, CYCLIN D2, p16INK4a, and p14ARF, so exerting a crucial role in tumor proliferation."
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"Apart from activating oncogenes such as BMI-1 and c-MYC , USP22 can inhibit the expression of tumor suppressors such as TP53 through ubiquitination , thus promoting proliferation of tumors [ 87 ] ."
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"Consistent with these findings, our data demonstrate that USP22 promotes gastric cancer cell proliferation, migration, and invasion in vitro and enhances tumor growth in vivo."
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"Based on these observations, the authors hypothesized that USP22 inhibition could simultaneously promote anti-tumor immunity and target tumors driven by USP22 upregulation and pathogenic H2Bub1 deplet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 knockdown reduces T cell-dependent tumor metastasis, increases the immunogenicity of tumors, increases the lymphatic invasion of tumors and natural killer cell activity [ 82 ], and enhances anti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Even when a higher number of 4T1 cells, 10 and 10 , were orthotopically injected, USP22 deletion inhibited the development of syngeneic tumors (Figures 1H and 1I), indicating that USP22 is critical for in vivo tumor initiation."
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"To date , no small molecule inhibitors of USP22 have been reported , but given mounting evidence in multiple contexts that USP22 promotes tumor progression , the development of such inhibitors would be desirable ."
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"Co-expression of USP22 and BMI1 can accelerate tumor proliferation, stemness, and drug resistance (35)."
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"Another study also revealed that USP22 depletion reduced cell cycle progression and retarded tumor growth in animal models of bladder cancer, liver cancer, lung cancer, breast cancer and ovarian cancer (51)."
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"As expected, the genetic deletion of USP22 notably inhibited MDA-MB-231 xenograft tumor growth in immunodeficient NYG mice, as evidenced by reduced tumor volume (Fig. 2B), luminol fluorescence activity (Fig. 2, C to E), and tumor weight (Fig. 2, F and G)."
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"In conclusion, USP22 is upregulated in a variety of malignancies, and studies have shown that USP22 induces tumor resistance to 5-FU by acting on CSCs, SIRT1, and C-MYC."
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"The inhibition of USP22 enhances the cytotoxicity of T cells and reduces tumor growth (28)."
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"Taken together, USP22 accelerates c‐Myc/NrasGV12‐induced tumorigenesis and promotes tumor progression through an FKBP12/mTORC1/autophagy positive feedback loop in HCC cells."
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"As expected, USP22 deletion inhibited 4T1 cancer colonization of the lung by reducing more than 60% of tumor nodules with further reduction in metastatic foci size (Figures 1J–1L)."
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"USP22 promotes lethal tumor phenotypes by modulating androgen receptor accumulation and oncogenic signaling in prostate cancer [ 25 ]."
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"Even when a higher number of 4T1 cells, 10 and 10 , were orthotopically injected, USP22 deletion dramatically inhibited the development of syngeneic tumors (Fig. 1H & 1I), indicating that USP22 is critical for in vivo tumor initiation."
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"As expected, USP22 deletion dramatically inhibited 4T1 cancer colonization to the lung by reducing more than 60% of tumor nodules with further reduced metastatic foci size (Fig. 1J–L)."
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"Moreover, USP22 ablation completely prevented lung metastasis, even in mice with tumors treated with EPI, because the lung luminol fluorescence activity and tumor nodules were both markedly decreased by USP22 deletion (Fig. 2, S to U)."
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"A more recently published report indicates that USP22 may promote tumor progression and induce EMT in colorectal carcinoma patients [ 13 ] ."
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"Unlike 5-FU resistance mechanisms, USP22 increases tumor resistance to cisplatin by enhancing DNA repair capacity."
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"The reduction of USP22 levels was found to suppress tumor growth and enhance the cytotoxicity of T cells."
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"In our study, we found that miR-485-5p inhibited the expression of USP22 in osteosarcoma cells, leading to suppression of viability and motility of osteosarcoma cells.USP22 promoted tumor development and progression in certain cancer types."
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"However, deletion of Usp22 significantly decreased tumor burden and increased survival of MMTV-NIC mice."
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"In vivo experiments reveal that USP22 knockdown in GC cells significantly reduces xenograft tumor growth and lung metastasis in SCID mice."
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"USP22 in PC cells interacts with SAGA/STAGA to affect the immune microenvironment, and USP22 deficiency promotes T-cell and NK cell infiltration and inhibits tumor metastasis (116)."
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"It has been reported that USP2a, USP7, USP21, and USP22 are highly expressed in the HCC tissue or cells and promote tumor development (Cai et al., 2015; Li et al., 2018; Ling et al., 2020; Xiong et al., 2021)."
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"Injection of VEGFA-165 partially restored the tumor growth inhibition induced by USP22 knockdown."
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"Previous studies have also shown that USP22 can promote tumor progression and induce EMT in various tumors [ 13 , 23 ] ."
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"Loss of Usp22 impacted both weight and volume of tumors and substantially reduced the numbers of tumors formed per mouse (Fig 3C–3E)."
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"USP22 can enhance c-Myc-mediated transcriptional activity and promote tumor development [ 23 , 60–62 ]."
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"In particular, inhibiting USP22 by CRISPR in Treg cells has been demonstrated to lower Foxp3 protein production as well as reduce tumor growth in different tumor types [103]."
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"Since depletion of USP22 expression has been reported to suppress tumor growth in various cancers other than MPM [ 14 , 19 ], we next examined the potential regulatory effect of USP22 on MPM cell prol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Despite these advances , the overall mechanisms by which USP22 contributes to cancer progression remain incompletely defined ."
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"USP22 is overexpressed and promotes tumor progression in multiple tumor types; the deletion of USP22 in pancreatic tumor cells promotes the infiltration of T-cells and NK cells, thus improving the response to combined immunotherapy (125)."
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"In addition, both Qiu et al. [ 66 ] and we have found that USP22 promotes tumor stemness via hypoxia-inducible factor 1 subunit alpha (HIF-1α) under hypoxia."
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"In sum , these studies identify USP22 as a regulator of the response to DNA damage , and ultimately define a major node by which USP22 promotes cancer phenotypes ."
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"As expected, USP22 deficiency dramatically impaired Treg suppressive function but increased the proportion of IFN-γ GrB CD8 T cells and significantly inhibited tumor growth in multiple cancer models [86]."
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
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"USP22 and RNF40 mediate tumor-promoting function of ALKBH5."
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"Altogether, these results suggested that USP22 enhanced the stabilization of c-Myc via its deubiquitinase activity.To determine whether USP22 enhances tumor-initiation frequency in vivo , a limiting d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In malignant tumors, the high expression of USP22 causes a variety of pathways that promote cell survival to be abnormally active [10–12] ."
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