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"It is noteworthy that EAG1 may be down-regulated by p53 and pRb pathways 76, indicating a potential synergistic effect of estrogen and HPV on EAG1 expression.The HERG potassium channel, a member of the EAG potassium channel family, has been identified in various cancer types, and HERG mRNA has been detected in HeLa cells 70."