IndraLab

Statements

TNF activates USP4. 6 / 7
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"It was shown that TNFalpha induces the association of USP4 with TAK1 and deubiquitylation of K63 linked ubiquitin chains from TAK1, leading to the inhibition of NF-kappaB production."
25007997
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"Consistently, we also found that TNFalpha induced co-immunoprecipitation of endogenous USP4 and TAK1 as well as IKKbeta and RIPK1 (XREF_FIG)."
21331078
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"To further determine the molecular interaction of USP4 and TAK1 in TNFalpha induced signal transduction, we overexpressed expression vector encoding MYC-USP4 in HEK-293T cells and treated with TNFalpha for the time points as indicated (XREF_FIG)."
21331078
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"These results suggest that TNFalpha induces association of USP4 with TAK1."
21331078
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"We found that TNFalpha induced co-immunoprecipitation of MYC-USP4 and TAK1 as well as IKKbeta and RIPK1 within 10 min of stimulation (XREF_FIG)."
21331078
reach
"To determine whether USP4 inhibits TNFalpha induced TAK1 polyubiquitination, we overexpressed MYC-USP4-WT and -C311A mutant with HA-Ub in HEK293T cells and treated with TNFalpha for the time points indicated."
21331078