IndraLab

Statements

FN1 phosphorylates PTK2B. 4 / 4
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"Our study on the role of Src in fibronectin-induced Pyk2 phosphorylation reveals another facet."
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"In FAK-null fibroblasts, FN stimulation in the presence of the PP1 inhibitor of Src-family PTKs or after overexpression of p50 csk (a negative regulator of Src-family PTKs), resulted in dramatically [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indeed, depletion of intracellular Ca2+ by using Ca2+ chelator BAPTA significantly reduces fibronectin-induced Pyk2 phosphorylation (data not shown), but whether this effect is Src-dependent or -independent remains to be determined."
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"Thus, these results suggest that fibronectin-induced tyrosine phosphorylation of Pyk2 and FAK at Y402 and Y397 sites, respectively, are differentially regulated by Src."
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