IndraLab

Statements

UCHL5 deubiquitinates TCF7. 4 / 4
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"Because Uch37 mediates deubiquitination of Tcf7 protein without affecting its stability, we next sought to elucidate the non proteolytic role of Uch37 mediated deubiquitination of Tcf7 and subsequent activation of Wnt signalling."
28198400
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"Here, we report that Uch37 mediates the deubiquitination of Tcf7 without affecting protein stability."
28198400
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"To further examine if Uch37 directly deubiquitinates Tcf7, we conducted in vitro deubiquitination assays using immunopurified Tcf7-ubiquitin conjugates."
28198400
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"However, deubiquitination of TCF7 by UCH37 is involved in TCF7 binding to the promoters of c-Myc, and Cyclin D1 [XREF_BIBR, XREF_BIBR]."
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