The INDRA Database

reach

"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells (XREF_SUPPLEMENTARY), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."

27440725

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sparser

"Given that NF-κB and STAT3 are often activated coordinately during tumorigenesis, we examined whether STAT3 was activated by USP6 in our established cellular models of ABC and NF."

27440725

➶

reach

"This validates our cellular model systems, and indicates that USP6 expression in human tumors triggers STAT3 and NF-kappaB signaling responses."

27440725

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sparser

"In these models, activation of STAT3, NF-κB, and β-catenin by USP6 was essential for tumorigenesis, as genetic or pharmacologic inhibition of these pathways significantly attenuated xenograft growth ( xref , xref , xref )."

33558334

➶

sparser

"We sought to dissect the mechanism by which USP6 activates STAT3."

27440725

➶

sparser

"Jak kinases mediate STAT3 activation by USP6 and are required for tumorigenesis."

27440725

➶

sparser

"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells ( xref ), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."

27440725

➶

reach

"USP6 activates STAT3 in cellular models and USP6 translocated tumors."

27440725

➶

reach

"Given that NF-kappaB and STAT3 are often activated coordinately during tumorigenesis, we examined whether STAT3 was activated by USP6 in our established cellular models of ABC and NF."

27440725

➶

reach

"We sought to dissect the mechanism by which USP6 activates STAT3."

27440725

➶

sparser

"Together, these results demonstrate that USP6 activates STAT3 exclusively through a Jak family kinase."

27440725

➶

reach

"Together, these results demonstrate that USP6 activates STAT3 exclusively through a Jak family kinase."