IndraLab

Statements

USP6 activates STAT3. 19 / 19
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"Together, these results demonstrate that USP6 activates STAT3 exclusively through a Jak family kinase."
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"Jak1 is required for STAT3 activation by USP6, and both are required for USP6-mediated cell survival and tumorigenesis."
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"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells (XREF_SUPPLEMENTARY), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."
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"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells ( xref ), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."
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"Henrich and Coll showed that USP6 modulates the IFN (interferon) response in ES cells by potentiating the activation of STAT1 and STAT3 [184] ."
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"Cells lacking JAK1 (USP6/TRE17) showed no activation of STAT3 caused by USP6."
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"JAK1 levels in this clone were similar to those in control NIH3T3 cells, indicating that USP6’s activation of STAT3 requires JAK1 overexpression."
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"In these models, activation of STAT3, NF-κB, and β-catenin by USP6 was essential for tumorigenesis, as genetic or pharmacologic inhibition of these pathways significantly attenuated xenograft growth ( xref , xref , xref )."
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"USP6 activates STAT3 in cellular models and USP6 translocated tumors."
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"Given that NF-kappaB and STAT3 are often activated coordinately during tumorigenesis, we examined whether STAT3 was activated by USP6 in our established cellular models of ABC and NF."
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"This validates our cellular model systems, and indicates that USP6 expression in human tumors triggers STAT3 and NF-kappaB signaling responses."
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"USP6 activation of STAT3 occurs independently of NF-kappaB."
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"We sought to dissect the mechanism by which USP6 activates STAT3."
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"Together, these results demonstrate that USP6 activates STAT3 exclusively through a Jak family kinase."
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"USP6 activates STAT3 in cellular models and USP6 -translocated tumors."
27440725
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"Given that NF-κB and STAT3 are often activated coordinately during tumorigenesis, we examined whether STAT3 was activated by USP6 in our established cellular models of ABC and NF."
27440725
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"USP6 activation of STAT3 occurs independently of NF-κB."
27440725
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"We sought to dissect the mechanism by which USP6 activates STAT3."
27440725
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"Jak kinases mediate STAT3 activation by USP6 and are required for tumorigenesis."
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