IndraLab

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OTUD7B leads to the deubiquitination of PIK3C3. 2 / 2
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"Besides, the enzymatic activity mutant Cezanne (C194S and H358R, Cezanne CH) could not decrease PIK3C3 ubiquitination (Fig. 4B), further confirming the deubiquitination effect of Cezanne on PIK3C3.To explore the motif or molecule basis of Cezanne and PIK3C3, we constructed plasmids composed of different part of these two proteins shown in Fig. 4C and Supplementary Fig. 1E."
37596251
reach
"CO-IP assays showed that Cezanne OE decreased PIK3C3 ubiquitination and induced a significant decrease of the K48-linked ubiquitination and a slight decrease of K11-linked ubiquitination of PIK3C3 (Fig. 4A), which were reported to mediate the degradation of target molecules [20]."
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