IndraLab

Statements

USP15 inhibits TGFB. 5 / 7
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"In this context, to achieve a certain biological outcome, the same DUB can regulate the pathway at different levels (e.g., USP15 and USP4 promote signaling by targeting the TGF-beta receptor and the effector SMADs) or multiple DUBs can act on the same target (e.g., USP15 and OTUB1 promote signaling through stabilizing R-SMADs)."
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"Thus, Scaf1 and Usp15 knockout cells share several alterations such as upregulated TNFα signaling and downregulated TGFβ, hedgehog and p53 signaling but also several distinct pathways."
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"Downregulation or inhibition of USP15 in a patient derived orthotopic mouse model of glioblastoma decreases TGF-beta activity."
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"Furthermore, either silencing TGFBR2 or USP15 or blocking activity of TGF-β signaling using LY2109761, a novel selective TGF-β receptor type I/II dual inhibitor (Melisi et al. 2008), differentially abrogated the stimulatory effect of MFSD4A-AS1 on invasive and migration abilities of PTC cells (Supplementary Fig. 6A and B)."
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"USP15 mediated activation of the TGF-beta pathway is inhibited by a catalytically inactive mutant of SMURF2."
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