IndraLab

Statements

USP15 inhibits TGFB. 3 / 5
| 3
reach
"USP15 mediated activation of the TGF-beta pathway is inhibited by a catalytically inactive mutant of SMURF2."
26435193
reach
"In this context, to achieve a certain biological outcome, the same DUB can regulate the pathway at different levels (e.g., USP15 and USP4 promote signaling by targeting the TGF-beta receptor and the effector SMADs) or multiple DUBs can act on the same target (e.g., USP15 and OTUB1 promote signaling through stabilizing R-SMADs)."
33335288
reach
"Downregulation or inhibition of USP15 in a patient derived orthotopic mouse model of glioblastoma decreases TGF-beta activity."
22344298