IndraLab

Statements

USP29 binds CGAS and K48. 3 / 3
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"Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48 linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection."
32457395
reach
"[208] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48 linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV-1 stimulation."
33511009
reach
"USP29 constitutively interacts with cGAS and deconjugates K48 linked polyubiquitin chains from cGAS in the absence or presence of HSV-1 infection, which stabilizes cGAS and promotes cGAS mediated cellular antiviral responses."
32457395