IndraLab

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USP15 binds IL1R2. 5 / 5
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"The initial screening identified a number of protein candidates in the SUM159‐IL1R2/‐sIL1R2 and MB231‐IL1R2/‐sIL1R2 cells (Table S5, Supporting Information), among them, we did not find the previous reported ubiquitin Ligases or deubiquitinase of BMI1 such as βTrCP,19 RING1B,20 or USP22,21 but we found that IL1R2 could bind to USP15 (Figure 4 A)."
31921558
sparser
"These results indicated that IL1R2 could bind to USP15 and increases the deubiquitination and stability of BMI1 protein, which then promotes BTIC enrichment and BC progression."
31921558
sparser
"Here, we found that IL1R2 intracellular domain (icd‐IL1R2) could bind to the deubiquitinase USP15 at the UBL2 domain and promoted USP15 deubiquitinase activity on BMI1 protein deubiquitination at K81 and finally increased BMI1 stability in BC cellular nucleus."
31921558
sparser
"The initial screening identified a number of protein candidates in the SUM159‐IL1R2/‐sIL1R2 and MB231‐IL1R2/‐sIL1R2 cells (Table S5, Supporting Information), among them, we did not find the previous reported ubiquitin Ligases or deubiquitinase of BMI1 such as βTrCP, xref RING1B, xref or USP22, xref but we found that IL1R2 could bind to USP15 ( Figure xref A)."
31921558
reach
"These results indicated that IL1R2 could bind to USP15 and increases the deubiquitination and stability of BMI1 protein, which then promotes BTIC enrichment and BC progression.2."
31921558