IndraLab

Statements

USP22 activates Hypoxia. 4 / 4
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"19 Moreover, current evidence suggests that USP22 could promote hypoxia‐induced HCC glycolysis and stemness by deubiquitinating and stabilizing HIF‐1α."
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"In addition, USP22 can promote hypoxia-induced generation of liver cancer stem cells through the HIF1α/USP22 positive feedback loop after p53 inactivation, and lipoprotein complexes targeting USP22 can inhibit the growth of liver cancer cells and enhance sorafenib sensitivity (77)."
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"27 Ubiquitin‐specific protease 22 (USP22) can promote hypoxia‐induced hepatocellular carcinoma (HCC) stemness and glycolysis by deubiquitinating and stabilizing HIF1α."
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"23 In the absence of TP53, we found that USP22 enhanced hypoxia‐induced stemness, 13 which facilitated us to further investigate the relationship between USP22 and hepatotumorigenesis."
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