IndraLab

Statements

TLR4 binds USP8. 3 / 3
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sparser
"According to recent studies, the inhibition of autophagy induced by TLR4 interacted with USP8, promoting liver cancer pathogenesis and progression ( Kim et al., 2022; Son et al., 2021 )."
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sparser
"Collectively, these findings position DUBs as master regulators of neuroinflammatory and neuroprotective responses in CIRI, operating through: (i) direct ubiquitin code editing of inflammasome components (BRCC3-NLRP6, CYLD-NLRP3), (ii) multi-layered control of NF-κB signaling (A20/TRAF6, CYLD-TRAF2/6, OTUD1/RIP2, USP25/TAB2), (iii) dynamic modulation of microglial polarization states (USP8-TLR4, USP14-REST), and critically, (iv) axonal integrity preservation via UCHL1-mediated stabilization of synaptic scaffolds (PSD-95/neurofilaments), offering a compelling therapeutic paradigm for targeted immunomodulation in IS."
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reach
"Among them, Usp8, Usp9x, and Usp20 bound to TLR4 most tightly (Figure 1J)."
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