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USP22 deubiquitinates KDM1A. 8 / 8
1 | 7

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"These results indicate that USP22 deubiquitinates and stabilizes KDM1A."

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"Moreover, using in vitro deubiquitination assay, we found that KDM1A ubiquitination was decreased by incubating with recombinant USP22, suggesting that USP22 deubiquitinates KDM1A directly (XREF_FIG)."

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"In addition, deubiquitination of KDM1A by USP22 was attenuated after GSK3beta knockdown (XREF_FIG)."

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"USP22 deubiquitinated LSD1 in RB."

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"A screen for DUBs that could stabilize KDM1 demonstrates USP15, USP21, USP22 and USP28 as potential hits, among which ectopic expression of USP22 reduced KDM1A ubiquitination levels strikingly."

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"However, of those four DUBs, only USP22 substantially decreased KDM1A ubiquitination (XREF_SUPPLEMENTARY)."

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"Furthermore, knockdown of USP22 in GSC11 cells increased KDM1A ubiquitination (XREF_FIG)."