IndraLab

Statements

USP22 deubiquitinates KDM1A. 7 / 8
1 | 7
reach
"A screen for DUBs that could stabilize KDM1 demonstrates USP15, USP21, USP22 and USP28 as potential hits, among which ectopic expression of USP22 reduced KDM1A ubiquitination levels strikingly."
32723561
reach
"In addition, deubiquitination of KDM1A by USP22 was attenuated after GSK3beta knockdown (XREF_FIG)."
27501329
reach
"USP22 deubiquitinated LSD1 in RB."
33475455
reach
"However, of those four DUBs, only USP22 substantially decreased KDM1A ubiquitination (XREF_SUPPLEMENTARY)."
27501329
reach
"Moreover, using in vitro deubiquitination assay, we found that KDM1A ubiquitination was decreased by incubating with recombinant USP22, suggesting that USP22 deubiquitinates KDM1A directly (XREF_FIG)."
27501329
reach
"Furthermore, knockdown of USP22 in GSC11 cells increased KDM1A ubiquitination (XREF_FIG)."
27501329
reach
"These results indicate that USP22 deubiquitinates and stabilizes KDM1A."
27501329