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KRAS activates USP28. 6 / 6
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"JUN is involved in the transcriptional activation of USP28 in colorectal cancer (CRC) cells by activated KRAS."
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"The results of XREF_FIG showed that KRAS promoted the transcriptional upregulation of USP28."
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"Another molecule, KRAS, which plays a vital role in the signal transduction of most growth factor receptors, has been validated to increase the activity of c-Jun and upregulate USP28 [44–47]."
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"Furthermore, the reduction in USP28 in cells with c-Jun loss and the CHIP results indicate that c-Jun can make a connection with the USP28 promoter, revealing that c-Jun is responsible for the upregulation of USP28 caused by KRAS [47] (Fig. 3)."
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"JUN transcript is also responsible for KRAS-mediated transcriptional activation of USP28 in CRC."
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"JUN is involved in the transcriptional activation of USP28 in colorectal cancer (CRC) cells by activated KRAS."
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