IndraLab

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"Epigallocatechin gallate inhibits de novo mitochondrial DNA synthesis and ROS production in mouse macrophages and the NLRP3 inflammasome and prevents gouty inflammation (72)."
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"EGCG inhibited NLRP3 inflammation via de novo synthesis of mitochondrial DNA and generation of reactive oxygen species in primary mouse macrophages."
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"EGCG reduced Hla-induced ROS overproduction and MAPK signaling pathway activation, thereby significantly attenuating NLRP3 inflammasome-associated protein expression in THP-1 cells."
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"Tian et al. (2020) demonstrated that EGCG inhibited cellular inflammation and apoptosis in human degenerative NP cells by inhibiting the activation of NLRP3."
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"The canonical inflammasome, the NLRP3 inflammasome, was activated by high glucose levels and inhibited by pro-EGCG treatment."
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"EGCG, known for its anti-oxidant property (Mokra et al., 2022), also inhibits NLRP3 inflammasome (Zhang et al., 2021)."
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"For instance, EGCG abundant in tea can inhibit NLRP3 inflammasome conjugation with thioredoxin-interacting protein (TXNIP) in THP-1 cells and ameliorate peritoneal inflammation by inhibiting NLRP3 expression and IL-1β release in monosodium urate (MSU) crystal-treated mice (Jhang et al., 2016)."
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"Thus, the negative effect of EGCG on the mRNA abundance of TLR4 signaling components, phosphorylation of IκBα, NF-κBp65, NLRP3 and caspase-1 protein abundance confirmed that EGCG elicit an anti-inflammatory response by preventing activation of the NF-κB pathway and NLRP3 inflammasome in ruminal epithelial cells.Because of its potential to eliminate pathogens (xenophagy) and activate immunity while limiting excessive inflammation, autophagy can impact immunity and inflammation [44]."
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"Concentration of NLRP3, which is closely linked with oxidative stress and inflammation, was significantly elevated in the silica-instilled animals compared to controls (both p < 0.05 after 14 and 28 days, while treatment with EGCG lowered NLRP3 concentration after 14 days (p < 0.05) (Figure 1)."
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"EGCG inhibits NLRP3 inflammation by blocking MSU crystal induced production of caspase-1 (p10) and interleukin-1beta in primary mouse macrophages."
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"EGCG alleviated CUMS-induced depression-like behavioral changes in mice, reduced activation of the NLRP3 inflammasome, inhibited the mTOR signaling pathway, restored autophagy levels, reduced apoptosis marker expression and attenuated abnormal changes in blood lipid levels."
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"The polyphenolic Epigallocatechin-3 Gallate (EGCG) has been shown to prevent acute gout through its anti-inflammatory activity by suppressing the activation of the NLRP3 inflammasome, acting as a modulator of Lysine Acetyl Transferase (KAT) (50)."
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"We further examined the impact of EGCG on NLRP3 inflammasome activation and found that EGCG decreased both gene and protein expression of key signaling proteins in the TXNIP/NLRP3/IL‐1β axis, including TXNIP, ASC, NLRP3, caspase1, and IL‐1β (Figure 4B–D)."
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"This suggests that EGCG and fluoxetine significantly inhibit NLRP3 activation in a stress‐induced mouse depression model, which hinders the inflammatory response and reduces depressive symptoms.3.3 EGCG improves CUMS-induced autophagy injury issues in the mouse brain."
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"Our results were consistent with those of Lee et al. (2019), who demonstrated that EGCG, a kind of catechin compounds, prevented acute gout by suppressing the activation of NLRP3 inflammasome in macrophages."
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"Furthermore, a study by Zhong et al. [162] found that EGCG inhibits the activation of typical NLRP3 and atypical caspase-11-dependent inflammasomes in primary rat microglia and the hippocampus of APP/PS1 mice induced by lipopolysaccharide (LPS) + Aβ through the toll-like receptor 4 (TLR4)/NF-κB pathway, reducing microglial inflammation and neurotoxicity."
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"Furthermore, EGCG inhibited renal NLRP3 inflammasome activity, and the expressions of NLRP3, caspase-1, and IL-1beta were also reduced, possibly due to the EGCG induced attenuation of NFkappaB pathway activity."
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"As mitochondria are a known target for the anti-inflammatory effects of EGCG [27] , we investigated whether EGCG inhibition of NLRP3 inflammasome is mediated by the repair of mitochondrial damage."
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"Thus, EGCG inhibits NLRP3 inflammasome through a common activation mechanism (shared by a wide range of proinflammatory activators)."
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"These results suggest that mtROS reduction is not a critical factor for EGCG-mediated inhibition of NLRP3 inflammasome activation.In addition, we used MitoTracker Deep Red (a fluorescent probe sensiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data provide clear evidence that EGCG suppresses NLRP3 inflammasome-mediated IL-1β secretion and caspase-1 activation in both human and mouse macrophages.We next investigated the mechanism of EG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results indicated that EGCG exerted anti-inflammatory activity in LPS-challenged BREC, particularly when incubated with 50 µmol/L EGCG for 6 h. EGCG promotes NLRP3 inflammasome degradation via activating autophagy, a critical aggravator of LPS-challenged systemic damage."
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"Citral and epigallocatechin-3-gallate (EGCG), both bioactive compounds derived from traditional Chinese medicine, prevent NLRP3 activation in vivo in mouse models of lupus and improve nephritis by protecting cells from oxidative damage."
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"Compared with the LPS group, 50 µmol/L EGCG pre-treatment for 6 h upregulated SQSTM1 and down-regulated MAP1LC3 transcription (Fig. 6A and B), and significantly reduced NLRP3 inflammasome and cleaved caspase-1 expression at the mRNA abundance level (Fig. 6C and D)."
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"Thus, EGCG impeded efficient assembly of the inflammatory complex.As mitochondrial transport and co-localization of ASC and NLRP3 are mediated by acetylated α-tubulin [30] , we next investigated the i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This finding revealed a novel mechanism by which flavanol phytochemicals exerts their anti-inflammatory effects and cardiovascular benefits.A recent study reporting the effect of dietary phytochemical[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In murine macrophages, EGCG was described to prevent IL-1β induction, possibly by inhibiting NLRP3 activation [56]."
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"The binding interaction of EGCG to Hla and the prevention of (Hla) 7 assembly by EGCG may contribute to the decrease of hemolytic activity of S. aureus and the inhibition of NLRP3 inflammasome activat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Advanced in vitro study that EGCG could block the activation of NLRP3 inflammasome through down-regulation of cGAS-STING-IRF3 pathway, and thus had significant protective effects against H O -induced apoptosis and inflammation in myeloid cells [218]."
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"Mechanistically, EGCG was revealed to repress the activation of macrophage NLRP3 inflammasome, a critical trigger of HBV-induced liver fibrosis."
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"For example, quercetin, luteolin, and epigallocatechin gallate inhibit TXNIP/NLRP3 by reducing ROS in ECs (Wu et al., 2014)."
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