IndraLab

Statements

COPS5 activates COPS5. 8 / 8
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"Analysis of EGFR and Jab1 expression in a cohort of invasive breast tumors by tissue microarray and immunohistochemistry confirmed a relationship between EGFR and increased nuclear Jab1 within the ERalpha - subset (n = 154, P = 0.019)."
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"CSN5 over-expression increases CSN5 but does not increase the COP9 signalosome whereas CSN5 down-regulation gives rise to an altered signalosome lacking CSN5 subunit and thus isopeptidase activity and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistently, STAT3 silencing decreases the expression of Jab1/CSN5 and inhibits Jab1/CSN5 promoter activity in cancer cell lines ."
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"Overexpression of JAB1 enhanced CPNE1-dependent differentiation of HiB5 indicating a synergistic effect of JAB1 and CPNE1 during neuronal differentiation even though the underlying mechanism deserves further clarification (Yoo et al. 2018)."
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"In anaplastic carcinoma, the incidence of jab1 overexpression increased significantly, strongly indicating the contribution of jab1 to thyroid carcinoma developing an extremely aggressive phenotype th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of CSN5 produces a free CSN5 protein pool, which stimulates the degradation of EB1."
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"The negative effect of CRE on cell growth was specific to the elimination of CSN5/Jab1 because ectopic introduction of wild-type CSN5/Jab1 rescued the proliferative defect of CSN5/Jab1 −/f + CRE ( Fig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Tomoda et al. [18] showed that the N-terminal half of JAB1/CSN5 (residues 1–190 including the MPN domain) mediates the binding of JAB1 to the cell cycle inhibitor p27."
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