IndraLab

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Oxycodone inhibits KCNH2. 5 / 5
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"The authors of the study speculated that high levels of oxycodone could lead to hERG channel inhibition, QTc prolongation, and sudden cardiac death [128]."
22905834
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"Fanoe et al. [67] reported that oxycodone inhibits hERG channels, albeit with very low affinity (IC50 = 171 microM), and that there was a dose dependent relationship between oxycodone dose and QTcB interval prolongation in patients (n = 26) treated for chronic non malignant pain."
22568597
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"Also, oxycodone inhibited hERG channels expressed in HEK293 cells (IC = 171 uM) with very low affinity compared to IC value of greater than 300 μM projected for the inhibitory effect of PF614 on hERG potassium currents in present project."
31362032
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"35 Oxycodone and fentanyl reduce HERG current in vitro, XREF_BIBR, XREF_BIBR and as do cocaine and cocaine metabolites, XREF_BIBR, XREF_BIBR but none of these drugs affect the I Ks current."
21895724
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"Methadone is the opiod most tightly associated with QTc prolongation; with much lesser potency buprenorphine and oxycodone can block HERG channels and depress the IKr current in vitro.Antineoplastic chemotherapy like anthracyclines, alkylating drugs, alkilants and cisplatin are associated with electrocardiographic alterations including prolongation of QT and emesis of different grades."
20210727