IndraLab

Statements

UCHL1 decreases the amount of CDKN1A. 2 / 2
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"In contrast, UCHL1 silencing or inhibition in PEM-R cells decreased the levels of c-Myc and Cyclin D1 and increased the levels of p21 (a cell cycle arrest related protein)."
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"We further found that UCHL1 induced p53 accumulation and reduced MDM2 protein level, and subsequently upregulated the expression of p21, as well as cleavage of caspase3 and PARP, but not in catalytic mutant UCHL1 C90S expressed cells."
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