IndraLab

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"Using deubiquitinase siRNA library screening based on an in vitro wound healing assay, we found that silencing BAP1 significantly augmented MSC migration."
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"BAP1 deficiency enhances MSC migration ."
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"BAP1 overexpression reduces MSC migration."
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"Transwell migration and invasion assays revealed that BAP1 overexpression inhibited MSC migration and invasion (Fig. 2E, F)."
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"We observed an increase in ERK1/2 phosphorylation in the BAP1-depleted MSC, whereas other signaling molecules (AKT serine 473, focal adhesion kinase tyrosine 925, p38 mitogen-activated protein kinases, and vimentin) remained unchanged (Fig. 3A)."
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"BAP1 depletion enhanced MSC migration, whereas BAP1 overexpression reduced MSC migration."
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