IndraLab

Statements

USP15 binds csn. 8 / 8
| 8
sparser
"However, in human cells, the interaction of CSN with USP15 is mediated by diverse mechanisms, but the specific subunits or variants involved in this interaction are still unknown."
33946990
sparser
"In addition to direct deneddylation, and steric hindrance, the CSN can associate with the de-ubiquitylating enzyme USP15."
26437438
sparser
"The CSN is associated with USP15 protecting BTB3 protein against destabilization as shown in S. pombe ( xref )."
23213463
sparser
"Binding of USP15 to the CSN seems to be conserved."
32708147
sparser
"The stabilizing effect of CSN5 toward IκB-α in stimulated cells was explained both by CSN5-mediated deNEDDylation of cullins, controlling CRL activity, and the association of the CSN with the deubiquitinase USP15 [ xref , xref , xref , xref ]."
31195722
sparser
"The CSN supercomplex regulates the balance between β-catenin and APC: while it stimulates β-catenin degradation, USP15 associated with the CSN stabilizes APC."
24594309
sparser
"USP15 is bound to the CSN complex, and a recent study showed that the Cullin-RING ubiquitin ligase (CRL), as a CSN-binding partner, is associated with USP15 [34, 35]."
| PMC
sparser
"Moreover, the CSN is associated with the Ub-specific protease USP15, a de-ubiquitinating enzyme that protects proteins from auto-ubiquitination and degradation."
21530537