IndraLab

Statements

USP13 binds TWIST1. 16 / 16
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sparser
"Here, we investigated a potential physical/functional interaction between Twist1 and USP13 in human breast cancer."
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"USP13 directly interacts with Twist1."
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"Although the biochemical and molecular functions of USP13 have been explored in various human cancers, including breast cancer, the oncogenic or tumor suppressor roles of USP13 in different studies has remained controversial.Here, we investigated a potential physical/functional interaction between Twist1 and USP13 in human breast cancer."
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"In accordance with the observed association between USP13 and Twist1, we detected an efficient co-precipitation between endogenous USP13 and Twist1 in SUM159PT and MDA-MB231 cells (Fig. 2a)."
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"We found that USP13 and Twist1 can form a negative feedback loop to jointly regulate the migration and invasion of breast cancer cells."
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"We also found that USP13 can directly interact with Twist1 and specifically cleave the K48-linked polyubiquitin chains of Twist1 induced by FBXL14."
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"The interaction between USP13 and Twist1 was further confirmed by IF analysis since we found that USP13 co-localizes with Twist1 in the nuclei of MDA-MB231 cells (Fig.  xref )."
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"The interaction between USP13 and Twist1 was further confirmed by IF analysis since we found that USP13 co-localizes with Twist1 in the nuclei of MDA-MB231 cells (Fig. 2d)."
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"Therefore, the above findings indicate a direct interaction between USP13 and Twist1."
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"For instance, USP13 directly interacts with Twist1 and cleaves FBXL14-induced K48-linked polyubiquitin chains, increasing Twist1 protein levels and facilitating BC cell migration and tumor metastasis in vitro and in vivo xref ."
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biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
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No evidence text available
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sparser
"Therefore, the above findings indicate a direct interaction between USP13 and Twist1."
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sparser
"While the expression of Twist1 could be regulated by USP13, USP13 interacts with Twist1 and stabilizes its expression via the ubiquitin-proteasome pathway."
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