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USP13 ubiquitinates α-synuclein. 3 / 3
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"Here, it was shown that USP13 negatively regulates Parkin ubiquitination, function, and solubility (Figure 5), negatively regulates the level, ubiquitination, and clearance of α-synuclein, and regulates proteasome activity independently of Parkin, which affects dopaminergic neuronal viability and motor performances in animal models."
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"The reduced ubiquitination and clearance of α-synuclein by USP13 was verified in vivo in transgenic mice with expression of mutant α-synuclein."
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"This perspective suggests that the monoubiquitinated α-synuclein should be extensively managed.Inhibition of USP13 enhances ubiquitination of α-synuclein, and causes the removal of α-synuclein through[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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