IndraLab

Statements

Poly I:C inhibits IFIH1. 2 / 2
| 2
reach
"Although the induction of IFN-beta by AIV was weaker than that after poly I : C stimulation (probably due to viral NS1 mediated inhibition of MDA5 signaling and induction of IFN-beta activity), our results agree with those of a previous study showing that silencing of cMDA5 and cTLR3 in WT cells results in a significantly reduced induction of IFN-beta activity after stimulation with poly I : C or infection of AIV."
32425931
reach
"When the RLRs were simultaneously overexpressed in the poly I : C transfected cells, the activity of LGP2 promoter did not significantly change although the MDA5 overexpressing cells stimulated by 80 and 400 ng poly I : C were slightly decreased compared to the others."
23251565