IndraLab

Statements

reach
"In contrast to BRCC36, USP16 and USP3, OTUB1 inhibits the DSB ubiquitin response downstream of RNF8, at the level of RNF168."
21056014
reach
"Remarkably, depletion of OTUB1 restored a pharmacologically disabled DSB response, indicating that targeting the OTUB1-E2 interaction might be an attractive route for the development of agents that bolster DSB repair.Another important example of the role played by DUBs in DNA repair relates to USP1, a DUB that modulates both FANCD2/FANCI and PCNA ubiquitylation [196, 197] ."
21056014
reach
"The otubain family DUB OTUB1 negatively regulates DSB dependent ubiquitination differently than these DUBs."
24560272