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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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OTUB1 inhibits DNA Breaks, Double-Stranded. 3 / 3

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"In contrast to BRCC36, USP16 and USP3, OTUB1 inhibits the DSB ubiquitin response downstream of RNF8, at the level of RNF168."

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"Remarkably, depletion of OTUB1 restored a pharmacologically disabled DSB response, indicating that targeting the OTUB1-E2 interaction might be an attractive route for the development of agents that bolster DSB repair.Another important example of the role played by DUBs in DNA repair relates to USP1, a DUB that modulates both FANCD2/FANCI and PCNA ubiquitylation [196, 197] ."

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"The otubain family DUB OTUB1 negatively regulates DSB dependent ubiquitination differently than these DUBs."

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OTUB1 inhibits DNA Breaks, Double-Stranded. 3 / 3

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