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"Furthermore, chronic administration of fluoxetine and vortioxetine decreased Arc and c-Fos, but not Egr1 in the frontal cortex, hippocampus and amygdala of rodents."

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"The Tukey’s HSD multiple comparisons test showed that diabetic rats had significantly higher densities of c-Fos immunoreactive cells than those of the control group (p < 0.001), and vortioxetine treatment at both doses decreased these enhanced densities of c-Fos immunopositive cells [F (3, 28) = 124.1; p < 0.001]."