IndraLab

Statements



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"Using RNAi, we found that certain deubiquitinases, BAP1, USP14 and OTUD5 each promote proviral transcription."

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"Although the -10 region is less conserved, there is a TGT motif one base upstream of the -10 region which is known to enhance transcription XREF_BIBR, XREF_BIBR."

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"Among the former DUBs, USP14 has been proposed to modulate transcription factors such as Bcl6 and BACH1."

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"A study by Doeppner et al. (2013) found that miR-124 reduces expression of the target deubiquitinating enzyme Usp14, thereby increasing repressor-element-1-silencing transcription factor degradation."

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"USP14 and UCHL5 inhibitors promote ERalpha degradation and inhibit ERalpha transcription activity."